Three young children were killed, and two adults seriously injured, in an early-morning fire at a home in West Baltimore.

The blaze broke out around 2:30 a.m. at a two-story rowhome in the 3000 block of Brighton Street, in the Rosemont neighborhood. Four people inside the home and a man who was outside when firefighters arrived were taken to the hospital, said Assistant Chief Roman Clark.

A 1-year-old boy, a 2-year-old boy and a 7-year-old girl were later pronounced dead. A woman was in critical condition, while the man was reported in critical condition but later released.

Charles A. Pleasant, 65, was in a home across the street when he awoke to the fire. He said a woman ran outside yelling, “My babies! My babies!” Pleasant said flames were shooting out of the second floor, and he later saw a man being taken away from the scene on a gurney.

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”That was an overwhelming fire,” he said. “I’ve seen some bad ones, but that was the worst.”

Burned belongings from inside the home were piled in the front yard late Saturday morning, including a blue-and-red plastic sippy cup and children’s toys.

The cause of the fire is under investigation.

Mayor Brandon Scott said in a statement that he was “heartbroken” by the deaths, and praised firefighters for their efforts.

“In the aftermath of this tragedy, we are committed to supporting those affected in every way we can,” Scott said in the statement. “We will work closely with the family, friends, and community members to provide them with the resources and support they need during this difficult time.”

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There have been five fire deaths across Baltimore in recent days. On Thursday, someone was found dead inside a burning home in the 800 block of Bradhurst Road in North Baltimore. And the Fire Department reported that another victim from a fatal fire that occurred in February at a Cherry Hill apartment building had died from his injuries.