A fatal head-on crash involving a Greyhound bus closed eastbound Maryland 32 at I-95 early Thursday morning in Howard County, officials said.

A Buick Enclave traveling west in the eastbound lanes of MD Route 32 collided with a Greyhound bus around 3:24 a.m. in the area of I-95, Howard County Police said.

The driver of the Buick, who was identified only as an adult male, was pronounced dead at the scene.

The Greyhound, which was carrying 38 passengers, had 17 passengers and the driver transported to an area hospital with non-life-threatening injuries.

All lanes on eastbound Maryland Route 32 were reopened by around 9 a.m. An investigation is ongoing.