Anthony Santander hit his second career grand slam, Gunnar Henderson homered for the second straight game and the AL-leading Baltimore Orioles remained unbeaten in Toronto this season, routing the Blue Jays 13-3 Tuesday night.
Santander went 3 for 4 with a walk and four RBIs. He cleared the bases with his 19th home run, a deep drive off Nate Pearson in the eighth.
Henderson went 3 for 5 with two RBIs, and Ryan Mountcastle reached base four times and drove in two runs as the Orioles won for the fourth time in five games and improved their league-best record to 66-41.
Right-hander Kyle Bradish (7-6) allowed three runs and four hits in seven innings, snapping a two-start losing streak. Bradish walked one and struck out seven.
Blue Jays catcher Danny Jansen hit a two-run home run and Brandon Belt added a solo shot, but Toronto fell to 1-7 against the Orioles, including 0-5 north of the border.
Toronto is 7-22 against AL East opponents.
Blue Jays left-hander Hyun Jin Ryu was activated off the injured list to make his season debut. The former All-Star had Tommy John surgery in June 2022.
Adley Rutschman and Mountcastle opened the game with back-to-back doubles and Santander followed with a single. Henderson drove in a run with a two-out fielder’s choice.
Ryu (0-1) allowed four runs and nine hits in five-plus innings, leaving after Henderson’s leadoff homer in the sixth. Ryu walked one and struck out three.
Jansen matched his career best with his 15th home run, connecting off Bradish in the second. Belt tied it at 3 with a one-out drive in the third, his ninth of the season.
Henderson broke the tie in the sixth with his 18th home run. He also hit a solo home run Monday.
Mountcastle’s second double of the game drove in a run in Baltimore’s three-run seventh against left-hander Génesis Cabrera.
After sitting out Monday, Blue Jays outfielder George Springer returned but went 0 for 4 with two strikeouts. Springer is hitless in 34 at-bats.
LHP Yusei Kikuchi (8-3, 3.79 ERA) will start for the Blue Jays on Wednesday night. RHP Grayson Rodriguez (2-2, 6.21) goes for the Orioles.