Anthony Santander hit his second career grand slam, Gunnar Henderson homered for the second straight game and the AL-leading Baltimore Orioles remained unbeaten in Toronto this season, routing the Blue Jays 13-3 Tuesday night.

Santander went 3 for 4 with a walk and four RBIs. He cleared the bases with his 19th home run, a deep drive off Nate Pearson in the eighth.

Henderson went 3 for 5 with two RBIs, and Ryan Mountcastle reached base four times and drove in two runs as the Orioles won for the fourth time in five games and improved their league-best record to 66-41.

Right-hander Kyle Bradish (7-6) allowed three runs and four hits in seven innings, snapping a two-start losing streak. Bradish walked one and struck out seven.

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Blue Jays catcher Danny Jansen hit a two-run home run and Brandon Belt added a solo shot, but Toronto fell to 1-7 against the Orioles, including 0-5 north of the border.

Toronto is 7-22 against AL East opponents.

Blue Jays left-hander Hyun Jin Ryu was activated off the injured list to make his season debut. The former All-Star had Tommy John surgery in June 2022.

Adley Rutschman and Mountcastle opened the game with back-to-back doubles and Santander followed with a single. Henderson drove in a run with a two-out fielder’s choice.

Ryu (0-1) allowed four runs and nine hits in five-plus innings, leaving after Henderson’s leadoff homer in the sixth. Ryu walked one and struck out three.

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Jansen matched his career best with his 15th home run, connecting off Bradish in the second. Belt tied it at 3 with a one-out drive in the third, his ninth of the season.

Henderson broke the tie in the sixth with his 18th home run. He also hit a solo home run Monday.

Mountcastle’s second double of the game drove in a run in Baltimore’s three-run seventh against left-hander Génesis Cabrera.

After sitting out Monday, Blue Jays outfielder George Springer returned but went 0 for 4 with two strikeouts. Springer is hitless in 34 at-bats.

Up next

LHP Yusei Kikuchi (8-3, 3.79 ERA) will start for the Blue Jays on Wednesday night. RHP Grayson Rodriguez (2-2, 6.21) goes for the Orioles.

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