Against the best offense the NFC has to offer, Ravens safety Kyle Hamilton proved he is one of the best defensive players in the AFC.

His five tackles, three pass defenses and two interceptions in a 33-19 win over the San Francisco 49ers earned him AFC Defensive Player of the Week honors for Week 16.

With his performance against the 49ers, Hamilton became the third defensive back since 2000 to record 10 or more tackles for loss (he’s at 10), 10 or more pass defenses (13) and four or more interceptions (four) in one season. Additionally, he has 81 tackles, including 63 solo tackles, which is the third-best on the Ravens. He also has four quarterback hits, including three sacks.

Hamilton accumulated the impressive stat line despite missing the end of the game. He has been playing with an injured MCL, suffered in Week 14, and he appeared to aggravate it in the fourth quarter. He was not scheduled to practice when the Ravens returned to the field Wednesday for a walk-through, and head coach John Harbaugh did not offer much of an update to his status.

“We’re less than 48 hours from the game,” Harbaugh said. “We’re just kind of working through all those kind things right now.”

Ravens officials were “optimistic” after the game that the injury was not serious.

“It doesn’t look bad for anybody,” Harbaugh told reporters post game.

Hamilton made highlight-reel plays against the Niners. After getting chop-blocked by running back Christian McCaffrey and then squished on the ground by guard Aaron Banks, he bounced back up to make his second interception of the night. The coaches had the team watch that play again Wednesday.

“I don’t know if he was playing possum or what,” Harbaugh said. “Maybe that was it. Maybe that’s why he got the interception. He came all out on a blitz; they high-lowed him — it was a good call. He got up and pursued.”

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The other players Harbaugh referenced in his post-game comments were offensive linemen Kevin Zeitler and Patrick Mekari, who left the game early in Santa Clara, California. Zeitler was listed as not participating in practice Wednesday, as well, with a knee/quad injury, while Mekari was limited due to a concussion.

Wide receiver Zay Flowers also was not available to practice due to a calf injury. Linebackers Roquan Smith (pectoral) and Patrick Queen (shoulder) were also limited, as were punter Jordan Stout (back) and defensive tackle Broderick Washington (elbow.) Cornerbacks Arthur Maulet (knee) and Jalyn Armour-Davis (concussion) were limited, as well, after missing the 49ers game.

Baltimore can secure the No. 1 seed in the AFC with a win against the Dolphins on Sunday, but Miami boasts the No. 3 offense in the league, according to FTN’s DVOA metric. The Dolphins will stress the Ravens defense even if stars Hamilton, Smith and Queen can get healthy enough to play.

Harbaugh also provided an update on tight end Mark Andrews, who was hurt during a play using the hip-drop tackle in the Week 10 game against the Cleveland Browns. Andrews, who was spotted with the team in the locker room late last week, remains on pace to potentially return should the Ravens make a deep playoff run.

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“I’ve seen him in there working,” Harbaugh said, “and he’s in great spirits, and we’re hopeful. Our job is to get to that point. That’s what we have to do is get to the point where we’re still playing when he comes back, and it’s going to take everything we have.”